Publications

2023

107. Morgan, J., Moreno, O., Alves, M., Baz, Z., Menéndez Méndez, A., Leister, H., . . . Engel, T. (2023). Increased uptake of the P2X7 receptor radiotracer 18F-JNJ-64413739 in the brain and peripheral organs according to the severity of status epilepticus in male mice. Epilepsia, 64(2), 511-523. doi:10.1111/epi.17484

106. Smith, J., Lopez-Avila, B. G., Engel, T., Mateos, E. M. J., & Alves, M. (2023). Differently expression of the metabotropic P2Y receptor family after hypoxia-induced seizures in neonates and seizure suppression via P2Y1 receptor agonism. Purinergic Signalling, doi:10.1007/s11302-023-09923-4

  1. Wong, Z.W., Engel, T. More than a drug target: Purinergic signalling as a source for diagnostic tools in epilepsy Neuropharmacology, 2023 Jan 1;222:109303. doi: 10.1016/j.neuropharm.2022.

2022

104.  Alves M, de Diego-Garcia L, Engel T. Analyzing the Role of the P2X7     Receptor in Epilepsy. Methods Mol Biol. 2022;2510:367-387.    doi:10.1007/978-1-0716-2384-8_21.

  1. Cleary, F, Srisa-An, W., Gil, B. J Kesavan, Engel T, Henshall, D.C., Balasubramaniam, S. Wearable Fabric μ Brain Enabling On-Garment Edge-Based Sensor Data Processing IEEE Sensors Journal, 2022, 22(21), pp. 20839–20854
  1. Gil B, Smith J, Tang Y, Illes P and Engel T. Beyond Seizure Control: Treating Comorbidities in Epilepsy via Targeting of the P2X7 Receptor. International Journal of Molecular Sciences. 2022 Feb 21;23(4):2380. doi: 10.3390/ijms23042380.

2021

  1. Wen-Jjing Jing Ren, Patrizia Rubini, Yong Tang, Tobias Engel and Peter Illes. Inherent P2X7 Receptors Regulate Macrophage Functions during Inflammatory Diseases, International Journal of Molecular Sciences, 2021 Dec 26;23(1):232. doi: 10.3390/ijms23010232
  1. BeamerE, James MorganJ, Alves M, Mendez MenendezA,MorrisG, ZimmerB, ConteG, de Diego-GarciaL, Alarcón-VilaC, Yiu NgNK, MaddenS, CalzaferriF, de los RiosC, GarciaAG, HamacherM, DinkelK, PelegrinP, HenshallDC, NickeA and Engel T. Increased expression of the ATP-gated P2X7 receptor reduces responsiveness to anti-convulsants during status epilepticus in mice. British Journal of Pharmacology, 2022 Jun;179(12):2986-3006. doi: 10.1111/bph.15785.
  1. Beamer E, O’DeaMI, GarveyAA,SmithJ, Menéndez-MéndezA, KellyL, PavelA, QuinlanS, AlvesM, Jimenez-MateosEM, TianF, DempseyE, DaleN, MurrayDM, BoylanGB,MolloyEJ and EngelT. Novel point-of-care diagnostic method for Neonatal Encephalopathy using purine nucleosides. Frontiers in Molecular Neuroscience, in press

98. Conte G, Menendez Mendez A, Bauer S, ElNaggar H, Alves M, Nicke A, Delanty D, Rosenow R, Henshall DC and Engel T.. Circulating P2X7 receptor signaling components as diagnostic biomarkers for temporal lobe epilepsy. Cells, 2021 Sep 16;10(9):2444. doi: 10.3390/cells10092444

  1. Méndez-lópez, I., Sancho-bielsa, F.J., Engel, T., García, A.G. and Padín, J.F. Progressive mitochondrial SOD1G93Aaccumulation causes severe structural, metabolic and functional aberrations through OPA1 down-regulation in a mouse model of amyotrophic lateral sclerosis. International Journal of Molecular Sciences, 2021, 22(15), 8194
  1. Tobias Engel, Jonathon Smith and Mariana Alves..Targeting neuroinflammation via purinergic P2 receptors for disease modification in drug refractory epilepsy. Journal of Inflammation Research, 2021 Jul 18;14:3367-3392. doi: 10.2147/JIR.S287740. eCollection 2021

95. Edward Beamer, Manvitha Kuchukulla, Detlev Boison, Tobias Engel. ATP and adenosine – two players in the control of seizures and epilepsy development. Progress in Neurobiology, 2021 Jun 16:102105.  

  1. Tobias Engel, Annette Nicke, Jan Deussing, Beata Sperlagh and Miguel Diaz-Hernandez. Editorial: The P2X7 receptor as a common therapeutic target in brain diseases, Frontiers in Molecular Neuroscience, Editorial, 2021 Apr 27;14:656011

93. Beamer E, Lacey A, Alves M, Conte G, de Diego-Garcia L, Khalil M, Rosenow F, Delanty N, El Naggar H, Henshall  DC & Engel T. Elevated blood purine levels are a biomarker of seizures and epilepsy. Epilepsia 62(3): 817-828. Link to paper here.  

92. Prades S, Heard G, Gale JE, Kopp R, Engel T, Nicke A, Smith KE & Jagger DJ. Functional P2X7 receptors in the auditory nerve of hearing rodents localize exclusively to peripheral glia. J Neurosci 41(12): 2615-2629. Link to paper here.

2020

91. Ramírez-Fernández A, Urbina-Treviño L, Conte G, Alves M, Rissiek B, Durner A, Scalbert N, Zhang J, Magnus T, Koch-Nolte F, Plesnila N, Deussing JM, Engel T, Kopp R & Nicke A. Deviant reporter expression and P2X4 passenger gene overexpression in the soluble EGFP BAC transgenic P2X7 reporter mouse model. Sci Rep 10(1): 19876. Link to paper here.

90. Menendez Mendez A, Smith J & Engel T. Neonatal Seizures and Purinergic Signalling. Int J Mol Sci 21(21): 7832. Link to paper here.

89. Conte G, Parras A, Alves M, Ollà I,  De Diego-Garcia L, Beamer E, Alalqam R, Ocampo A, Mendez R, Henshall DC, Lucas JJ & Engel T. High concordance between hippocampal transcriptome of the intraamygdala kainic acid model and human temporal lobe epilepsy. Epilepsia 61(12): 2795-2810 Link to paper here.

88. Brennan GP, Bauer S, Engel T, Jimenez-Mateos EM, Del Gallo F, Hill TDM, Connolly NMC, Costard LS, Neubert V, Salvetti B, Sanz-Rodriguez A, Heiland M, Mamad O, Brindley E, Norwood B, Batool A, Raoof R, El-Naggar H, Reschke CR, Delanty N, Prehn JHM, Fabene P, Mooney C, Rosenow F & Henshall DC. Genome-wide microRNA profiling of plasma from three different animal models identifies biomarkers of temporal lobe epilepsy. Neurobiol Dis  144: 105048. Link to paper here.

87. Almeida Silva LF, Reschke CR, Nguyen NT,  Langa E,  Sanz-Rodriguez A, Gerbatin RR,  Temp FR,  de Freitas ML,  Conroy RM, Brennan GP, Engel T & Henshall DC. Genetic deletion of microRNA-22 blunts the inflammatory transcriptional response to status epilepticus and exarcerbates epilepsy in mice. Mol Brain  13: 114. Link to paper here.

86. Morgan J,  Alves M, Conte G, Menendez-Menendez A, de Diego-Garcia L, de Leo G, Beamer E, Smith J, Nicke A and Engel T. Characterization of the expression of the ATP-gated P2X7 receptor following status epilepticus and during epilepsy using a P2X7-EGFP reporter mouse.Neuroscience Bulletin, in press.

 85. Conte G, Nguyen NT, Alves M, de Diego-Garcia L, Kenny A, Nicke A, Henshall DC, Jimenez-Mateos EM and Engel T. P2X7 receptor-dependent microRNA expression profile in the brain following status epilepticus in mice. Front Mol Neurosc, in press.

 84. Venø MT, Reschke CR, Morris G, Connolly NMC, Su J, Yan Y, Engel T, Jimenez-Mateos EM, Harder LM, Pultz D, Haunsberger SJ, Pal A, Heller JP, Campbell A, Langa E, Brennan GP, Conboy K, Richardson A, Norwood BA, Costard LS, Neubert V, Del Gallo F, Salvetti B, Vangoor VR, Sanz Rodriguez A, Muilu J, Fabene PF, Jeroen R, Prehn JHM, Schorge S, Andersen JS, Rosenow F, Bauer S, Kjems J and Henshall DC. A systems approach delivers a functional microRNA catalog and expanded targets for seizure suppression in temporal lobe epilepsy. PNAS, in press. Link to paper here.

 83. Parras A, de Diego-Garcia L, Alves M, Beamer E, Conte G, Jimenez-Mateos EM, Morgan J, Olla I, Hernandez-Santana Y, Delanty N, Farrell MA, O’Brien DF, Ocampo A, Henshall DC, Mendez R, Lucas JJ#  and Engel T#. mRNA polyadenylation as a novel regulatory mechanism of gene expression in temporal lobe epilepsy. Brain, in press. Link to paper here. #authors contributed equally

 82. Alves M#, Smith J# and Engel T. Differential expression of the metabotropic P2Y receptor family in the cortex following status epilepticus and neuroprotection via P2Y1 antagonism in mice. Front Pharmacol. 2020 Jan 16;10:1558. doi: 10.3389/fphar.2019.01558. Link to paper here. #authors contributed equally

81. Beamer E and Engel T, Using Amperometric, Enzyme-based Biosensors for Performing Longitudinal Measurements of Extracellular Adenosine 5-Triphosphate in the Mouse. Met Mol Biol. 2020;2041:197-207. Link to paper here.

2019

80. Kenny A, McArdle H, Calero M, Rabano A, Madden SF, Adamson K, Forster R, Spain E, Prehn JHM, Henshall DC, Medina M, Jimenez-Mateos EM# and Engel T#. Elevated plasma microRNA-206 levels predict cognitive decline and progression to dementia from mild cognitive impairment. Biomolecules, 2019 Nov 13;9(11). Link to paper here. #authors contributed equally

 79. Alves M#, Kenny A#, De Leo G, Beamer E and Engel T. Tau phosphorylation in a mouse model of temporal lobe epilepsy. Front Aging Neuros. 2019 Nov 12;11: 308. Link to paper here. #authors contributet equally

78. Kenny A, Jimenez-Mateos EM, Zea-Sevilla MA,  Rabano A, Gili-Manzanaro P, Prehn JHM, Henshall DC, Avila J, Engel T*, Hernandez F*. Proteins and microRNAs present in tear fluid as potential diagnostic biomarkers for Alzheimer’s disease. Sci Rep. 2019 Oct 28;9(1): 15437. Link to paper here.  *authors contributet equally

77. Alves M, De Diego Garcia L, Conte G, Jimenez-Mateos EM, D’Orsi B, Sanz-Rodriguez A, Prehn JHM, Henshall DC, Engel T.  Context-Specific Switch from Anti- to Pro-epileptogenic Function of the P2Y1 Receptor in Experimental Epilepsy. J Neurosci. 2019 Jul 3;39(27):5377-5392. Link to paper here.

76. Vangoor VR, Reschke CR, Senthilkumar K, van de Haar LL, de Wit M, Giuliani G, Broekhoven MH, Morris G, Engel T, Brennan GP, Conroy RM, van Rijen PC, Gosselaar PH, Schorge S, Schaapveld RQJ, Henshall DC, De Graan PNE, Pasterkamp RJ. Antagonizing Increased miR-135a Levels at the Chronic Stage of Experimental TLE Reduces Spontaneous Recurrent Seizures. J Neurosci. 2019 Jun 26;39(26):5064-5079. Link to paper here.

75. Beamer E, Conte G and Engel T. ATP Release During Seizures – A Critical Evaluation of the Evidence, Brain Res Bull, 2019 Jan 17. pii: S0361-9230(18)30739-1. Link to paper here.

2018

74. Kenny A, Hernandez F, Avila J, Lucas JJ, Henshall DC, Prehn HMJ, Jimenez-Mateos EM and Engel T. Profiling of Argonaute-2-loaded microRNAs in a mouse model of frontotemporal dementia with parkinsonism-17, Int J Physiol Pathophysiol Pharmacol, 2018 Dec 25;10(6): 172-183. Link to paper here.

73. Engel T. Regulation of P2X7 receptor expression and function in the brain, Brain Research Bulletin, 2018 Dec 26. pii: S0361-9230(18)30734-2. Link to paper here.

72. Beamer E, Jurado Arjona J, Jimenez-Mateos EM, J Morgan J, Reschke C, Kenny A, Olivos-Ore L, De Leon G, Arribas-Blazquez M, Merchan-Rubira J, Delanty N, Farrell M, O’Brien D, Avila J, Diaz-Hernandez M,  Miras-Portugal MT, Artalejo AR,  Hernandez F, Henshall DC and Engel T. MicroRNA-22 Controls Aberrant Neurogenesis and Changes in Neuronal Morphology after Status Epilepticus, Frontiers in Molecular Neuroscience, 2018 Dec 11;11:442. Link to paper here.

71. Engel T, Gomez-Sintes R, Alves M, Jimenez-Mateos EM, Fernández Nogales M, Sanz-Rodriguez A, Morgan J, Dunleavy M, Sano T, Avila J, Medina M, Hernandez F, Lucas JJ and Henshall DC (2018). Bi-directional genetic modulation of GSK-3B exacerbates hippocampal neuropathology in experimental epilepsy/status epilepticus. Cell Death and Disease, 2018 Sep 20;9(10):969. Link to paper here.

70. Kenny A, Jimenez-Mateos E, Calero M, Medina M, Engel T (2018). Detecting circulating microRNAs as biomarkers in Alzheimer’s disease. Methods in Molecular Biology, 2018; 1779:471-484. Link to paper here.

69. Kaczmarek-Hajek K, Zhang J, Kopp R, Grosche A, Rissiek B, Saul A, Bruzzone S, Engel T, Jooss T, Krautloher A, Schuster S, Magnus T, Stadelmann C, Sirko S, Koch-Nolte F, Eulenburg V, Nicke A, Re-evaluation of neuronal P2X7 expression using novel mouse models and a P2X7-specific nanobody. eLife. 2018 Aug 3;7. pii: e36217. Link to paper here.

68. Sebastian-Serrano A, de Diego-García L, Henshall D, Engel T, Diaz-Hernandez M. Haploinsufficient TNAP Mice Display Decreased Extracellular ATP Levels and Expression of Pannexin-1 Channels, Frontiers in Pharmacology, 2018 Mar 2;9:170. Link to paper here.

67. Alves M, Beamer EH and Engel T. The metabotropic purinergic P2Y receptor family as novel drug target in epilepsy, Frontiers in Pharmacology, 2018 Mar 7; 9:193. Link to paper here.

2017

66. Sanz Rodriguez A, Engel T, Palf Ai, Farrar GJ Henshall DC, Jimenez-Mateos EM. Tubby-like protein 1 (Tulp1) is a target of microRNA-134 and is down-regulated in experimental epilepsy. Int J Physiol Pathophysiol Pharmacol 2017;9(6):178-187. Link to paper here.

65. Alves M, Gomez-Villafuertes R, Delanty N, Farrell MA, O’Brien DF, Miras-Portugal MT, Diaz Hernandez M, Henshall DC and Engel T. Expression and function of the metabotropic purinergic P2Y receptor family in experimental seizure models and drug-refractory epilepsy patients. Epilepsia 2017 Jul 21. doi: 10.1111/epi.13850. Link to paper here.

64. Engel T, Lucas JJ and Hensahll DC. Targeting the proteasome in epilepsy. Oncotarget, 2017 Jul 11;8(28):45042-45043. Editorial. Link to paper here.

63. Quinlan S, Kenny A, Medina M, Engel T and Jimenez-Mateos EM. MicroRNAs in Neurodegenerative Diseases. International Review of Cell and Molecular Biology, 2017;334:309-343. Link to paper here.

62. Engel T, Martinez-Villarreal J, Henke C, Jimenez-Mateos EM, Sanz-Rodriguez A, Alves M, Hernandez-Santana Y, Brennan GP, Kenny A, Campbell A, Lucas JJ, Henshall DC. Spatiotemporal progression of ubiquitin-proteasome system inhibition after status epilepticus suggests protective adaptation against hippocampal injury. Mol Neurodegener. 2017 Feb 24;12(1):21. Link to paper here.

61. Rodriguez-Alvarez N, Jimenez-Mateos EM, Engel T, Quinlan S, Reschke CR, Conroy RM, Bhattacharya A, Boylan GB, Henshall DC. Effects of P2X7 receptor antagonists on hypoxia-induced neonatal seizures in mice. Neuropharmacology. 2017 Apr; 116:351-363. Link to paper here.

60. Beamer E, Fischer W, Engel T. The ATP-Gated P2X7 Receptor As a Target for the Treatment of Drug-Resistant Epilepsy. Front Neurosci. 2017 Feb 2;11:21. Link to paper here.

59. Engel T, Brennan GP, Sanz-Rodriguez A, Alves M, Beamer E, Henshall DC and Jimenez-Mateos EJ. A calcium-sensitive feed-forward loop regulating the expression of the ATP-gated purinergic P2X7 receptor via specificity protein 1 and microRNA-22, BBA. Molecular Cell Research, 2017 Feb;1864(2):255-266. Link to paper here.

58. Mooney CM, Jimenez-Mateos EM, Engel T, Mooney C, Diviney M, Venø MT, Kjems J, Farrell MA, O’Brien DF, Delanty N, Henshall DC. RNA sequencing of synaptic and cytoplasmic Upf1-bound transcripts supports contribution of nonsense-mediated decay to epileptogenesis. Sci Rep. 2017 Jan 27; 7:41517. Link to paper here.

57. Ichikawa N, Alves M, Pfeiffer S, Langa E, Hernández-Santana YE, Suzuki H, Prehn JH, Engel T, Henshall DC. Deletion of the BH3-only protein Noxa alters electrographic seizures but does not protect against hippocampal damage after status epilepticus in mice. Cell Death Dis. 2017 Jan 12;8(1):e2556. Link to paper here.

2016

56. Almeida Silva LF, Engel T, Reschke CR, Langa E and Henshall DC. Distinct behavioural and epileptic phenotype differences in 129/P mice compared to C57BL/6 mice subject to intra amygdala kainic acid-induced status epilepticus, Epilepsy & Behavior, 2016 Nov;64(Pt A):186-194. Link to paper here.

55. Gross C, Yao X, Engel T, Tiwari D, Xing L, Rowley S, Danielson SW, Thomas KT, Jimenez-Mateos EM, Schroeder LM, Pun RYK, Danzer SC, Henshall DC and Bassell GJ. MicroRNA-mediated downregulation of the potassium channel Kv4.2 contributes to seizure onset, Cell Reports, 2016 Sep 27;17(1):37-45. Link to paper here.

54. Sebastián-Serrano A, Engel T, de Diego-García L, Olivos Oré LA, Arribas-Blázquez M, Martínez-Frailes C, Pérez-Díaz C, Millán JL, Artalejo AR, Miras-Portugal MT, Henshall DC and Díaz-Hernández M. Neurodevelopmental alterations and seizures developed by mouse model of infantile hypophosphatasia are associated with purinergic signalling deregulation, Hum Mol Genet. 2016 Jul 27. pii: ddw248. Link to paper here.

53. Fischer W, Franke H, Krügel U, Müller H, Dinkel K, Lord B, Letavic MA, Henshall DC and Engel T. Critical Evaluation of P2X7 Receptor Antagonists in Selected Seizure Models, Plos One, 2016 Jun 9;11(6):e0156468. Link to paper here.

52. Jimenez-Pacheco A, Diaz-Hernandez M, Arribas-Blazquez M, Sanz-Rodriguez A, Olivos-Ore LA, Artalejo AR, Alves M, Letavic M, Miras-Portugal MT, Conroy R, Delanty N, Farrell M, O’Brien D, Bhattacharya A, Engel T* and Henshall DC*. Transient P2X7 Receptor Antagonism Produces Lasting Reductions in Spontaneous Seizures and Gliosis in Experimental Temporal Lobe Epilepsy. J Neurosci, 2016 Jun 1;36(22):5920-32. (*authors contributed equally. Link to paper here.

51. D’Orsi B, Engel T, Pfeiffer S, Nandi S, Kaufmann T, Henshall DC, Prehn JH. Bok Is Not Pro-Apoptotic But Suppresses Poly ADP-Ribose Polymerase-Dependent Cell Death Pathways and Protects against Excitotoxic and Seizure-Induced Neuronal Injury. J Neurosci. 2016 Apr 20;36(16):4564-78. Link to paper here.

50. Engel T. Purinergic signaling-induced neuroinflammation and status epilepticus. Expert Rev Neurother. 2016 Mar 30:1-3. Link to paper here.

2015

49. Jimenez-Mateos EM, Arribas-Blazquez M, Sanz-Rodriguez A, Concannon C, Olivos-Ore LA, Reschke CR, Mooney CM, Mooney C, Lugara E, Morgan J, Langa E, Jimenez-Pacheco A, Silva LF, Mesuret G, Boison D, Miras-Portugal MT, Letavic M, Artalejo AR, Bhattacharya A, Diaz-Hernandez M, Henshall DC, Engel T. microRNA targeting of the P2X7 purinoceptor opposes a contralateral epileptogenic focus in the hippocampus. Sci Rep. 2015 Dec 3;5:17486. Link to paper here.

48. Engel T, Alves M, Sheedy C, Henshall DC. ATPergic signalling during seizures and epilepsy. Neuropharmacology 2015 Nov 6. pii: S0028-3908(15)30165-9. Link to paper here.

47. Brennan GP, Jimenez-Mateos EM, Sanz-Rodriguez A, Mooney CM, Tzivion G, Henshall DC and Engel T. Overexpression of 14-3-3ζ Increases Brain Levels of the Protein CHOP. J Mol Neurosci. 2015 Feb 18. Link to paper here.

46. Henshall DC, Engel T. P2X purinoceptors as a link between hyperexcitability and neuroinflammation in status epilepticus. Epilepsy & Behav 2015 Apr 2. Link to paper here.

45. Jurado-Arjona J, Goñi-Oliver P, Rodríguez-Prada L, Engel T, Henshall DC, Ávila J, Hernández F. Excitotoxicity induced by kainic acid provokes glycogen synthase kinase-3 truncation in the hippocampus. Brain Res. 2015 Mar 14. Link to paper here.

44. D’Orsi B, Kilbride S, Chen G, Perez Alvarez S, Bonner H, Pfeiffer S, Plesnila N, Engel T, Henshall DC, Düßmann H and Prehn JH. Bax regulates neuronal Ca2+ homeostasis. J Neurosci, 2015 Jan 28;35(4):1706-22. Link to paper here.

2014

43. Sheedy C, Mooney C, Jimenez-Mateos EM, Sanz-Rodriguez A, Langa E, Mooney C and Engel T. De-repression of myelin-regulating gene expression after status epilepticus in mice lacking the C/EBP homologous protein CHOP. Int J Physiol Pathophysiol Pharmacol, 2014 Dec 15;6(4):185-98. Link to paper here.

42. Mesuret G, Engel T, Hessel EV, Sanz-Rodriguez A, Jimenez-Pacheco A, Miras-Portugal MT, Diaz-Hernandez M, Henshall DC. P2X7 receptor inhibition interrupts the progression of seizures in immature rats and reduces hippocampal damage. CNS Neurosci Ther 2014 Jun;20(6):556-64. Link to paper here.

41. Jimenez-Mateos EM, Engel T, Merino-Serrais P, Fernaud-Espinosa I, Rodriguez-Alvarez N, Reynolds J, Reschke CR, Conroy RM, McKiernan RC, deFelipe J, Henshall DC. Antagomirs targeting microRNA-13 increase hippocampal pyramidal neuron spine volume in vivo and protect against pilocarpine-induced status epilepticus. Brain Struct Funct. 2014 May 30. Link to paper here.

2013

40. Henshall DC, Diaz-Hernandez M, Miras-Portugal MT and Engel T. P2X receptors as target for the treatment of status epilepticus. Frontiers in Neuroscience, 2013 Nov 26; 7:237. Link to paper here.

39. Henshall DC and Engel T. Contribution of Apoptosis-Associated Signaling Pathways to Epileptogenesis: Lessons from Bcl-2 Family Knockouts. Frontiers in Neuroscience, 2013 Jul; 7:110. Link to paper here.

38. Jimenez Pacheco A, Mesuret G, Sanz-Rodriguez A, Tanaka K, Mooney C, Miras-Portugal MT, Diaz-Hernandez M, Henshall DC, Engel T. Increased neocortical expression of the P2X7 receptor after status epilepticus and neuroprotection by P2X7 receptor antagonist A438079. Epilepsia. 2013 Sep 54(9):1551-61. Link to paper here.

37. Moran C, Sanz-Rodriguez A, Jimenez-Pacheco A, Martinez-Villareal J, McKiernan RC, Jimenez-Mateos EM, Mooney C, Woods I, Prehn JH, Henshall DC, Engel T. Bmf upregulation through the AMP-activated protein kinase pathway may protect the brain from seizure-induced cell death. Cell Death Dis. 2013 Apr; 25; 4:e606. Link to paper here.

36. Torres-Peraza JF, Engel T, Martín-Ibáñez R, Sanz-Rodríguez A, Fernández-Fernández MR, Esgleas M, Canals JM, Henshall DC, Lucas JJ. Protective neuronal induction of ATF5 in endoplasmic reticulum stress induced by status epilepticus. Brain. 2013 Apr; 136(Pt 4):1161-76. Link to paper here.

35. Engel T, Sanz-Rodgriguez A, Jimenez-Mateos EM, Concannon CG, Jimenez-Pacheco A, Moran C, Mesuret G, Petit E, Delanty N, Farrell MA, O’Brien DF, Prehn JH, Lucas JJ, Henshall DC. CHOP regulates the p53-MDM2 axis and is required for neuronal survival after seizures. Brain. 2013 Feb; 136(Pt 2):577-92. Link to paper here.

34. Brennan GP, Jimenez-Mateos EM, McKiernan RC, Engel T, Tzivion G, Henshall DC. Transgenic overexpression of 14-3-3 zeta protects hippocampus against endoplasmic reticulum stress and status epilepticus in vivo. PLoS One. 2013;8(1):e54491. Link to paper here.

33. Caballero-Caballero A*, Engel T*, Martinez-Villarreal J, Sanz-Rodriguez A, Chang P, Dunleavy M, Mooney CM, Jimenez-Mateos EM, Schindler CK, Henshall DC. Mitochondrial localization of the Forkhead box class O transcription factor FOXO3a in brain. J Neurochem.; 2013 Mar 124(6):749-56. (*authors contributed equally). Link to paper here.

2012

32. Michalak Z, Sano T, Engel T, Miller-Delaney SF, Lerner-Natoli M, Henshall DC (2013). Spatio-temporally restricted blood-brain barrier disruption after intra-amygdala kainic acid-induced status epilepticus in mice. Epilepsy Res. 2012 Feb; 103(2-3):167-79. Link to paper here.

31. Engel T, Jimenez-Pacheco A, Miras-Portugal MT, Diaz-Hernandez M, Henshall DC. P2X7 receptor in epilepsy; role in pathophysiology and potential targeting for seizure control. Int J Physiol Pathophysiol Pharmacol. 2012; 4(4):174-87. Link to paper here.

30. Jimenez-Mateos EM, Engel T, Merino-Serrais P, McKiernan RC, Tanaka K, Mouri G, Sano T, O’Tuathaigh C, Waddington JL, Prenter S, Delanty N, Farrell MA, O’Brien DF, Conroy RM, Stallings RL, DeFelipe J, Henshall DC. Silencing microRNA-134 produces neuroprotective and prolonged seizure-suppressive effects. Nature Medicine. 2012 Jul 18(7):1087-94. Link to paper here.

29. Heverin M*, Engel T*, Meaney S, Jimenez-Mateos EM, Al-Saudi R, Henshall DC. Bi-lateral changes to hippocampal cholesterol levels during epileptogenesis and in chronic epilepsy following focal-onset status epilepticus in mice. Brain Res. 2012 Oct 1480:81-90. (*authors contributed equally). Link to paper here.

28. Avila J, Barreda E, Fuster-Matanzo A, Simón D, Llorens-Martín M, Engel T, Lucas J, Hernández M, Hernández F (2012). Looking for novel functions of tau. Biochem Soc Trans. 2012 Aug 40(4):653-5. Link to paper here.

27. McKiernan RC, Jimenez-Mateos EM, Bray I, Engel T, Brennan GP, Sano T, Michalak Z, Moran C, Delanty N, Farrell M, O’Brien D, Meller R, Simon RP, Stallings RL, Henshall DC. Reduced mature microRNA levels in association with dicer loss in human TLE with hippocampal sclerosis. PLoS One. 2012, 7(5):e35921. Link to paper here.

26. Engel T, Gomez-Villafuertes R, Tanaka K, Mesuret G, Sanz-Rodriguez A, Garcia-Huerta P, Miras-Portugal MT, Henshall DC, Diaz-Hernandez M. Seizure suppression and neuroprotection by targeting the purinergic P2X7 receptor during status epilepticus in mice. FASEB J. 2012 Apr 26(4):1616-28. Link to paper here.

2011

25. Jimenez-Mateos EM, Bray I, Sanz-Rodriguez A, Engel T, McKiernan R, Mouri G, Tanaka K, Sano T, Saugstad JA, Simon RP, Stallings RL and Henshall DC. MicroRNA expression profile after status epilepticus and hippocampal neuroprotection by targeting miR-132. Am J Pathol. 2011 Nov 179(5):2519-32. Link to paper here.

24. Engel T, Schindler CK, Sanz-Rodriguez A, Conroy RM, Meller R, Simon RP, Henshall DC. Expression of neurogenesis genes in human temporal lobe epilepsy with hippocampal sclerosis. Int J Physiol Pathophysiol Pharmacol 2011; 3(1):38-47. Link to paper here.

23. Engel T, Plesnila N, Prehn JH, Henshall DC. In vivo contributions of BH3-only proteins to neuronal death following seizures, ischemia, and traumatic brain injury. J Cereb Blood Flow Metab 2011 May 31(5):1196-210. Link to paper here.

22. Tsuchiya T, Bonner HP, Engel T, Woods I, Matsushima S, Ward MW, Taki W, Henshall DC, Concannon CG, Prehn JH. Bcl-2 homology domain 3-only proteins Puma and Bim mediate the vulnerability of CA1 hippocampal neurons to proteasome inhibition in vivo. Eur J Neurosci. 2011 Feb 33(3):401-8. Link to paper here.

2010-2005

21. Avila J, Gómez de Barreda E, Engel T, Lucas JJ, Hernández F. Tau phosphorylation in hippocampus results in toxic gain-of-function. Biochem Soc Trans. 2010 Aug 38(4):977-80. Link to paper here.

20. Engel T, Tanaka K, Jimenez-Mateos EM, Caballero-Caballero A, Prehn JH, Henshall DC. Loss of p53 results in protracted electrographic seizures and development of an aggravated epileptic phenotype following status epilepticus. Cell Death Dis 2010 Oct 7;1: e79. Link to paper here.

19. Engel T, Caballero-Caballero A, Schindler CK, Plesnila N, Strasser A, Prehn JH, Henshall DC. BH3-only protein Bid is dispensable for seizure-induced neuronal death and the associated nuclear accumulation of apoptosis-inducing factor. J Neurochem 2010 Oct 115(1):92-101. Link to paper here.

18. Engel T, Hatazaki S, Tanaka K, Prehn JH, Henshall DC. Deletion of puma protects hippocampal neurons in a model of severe status epilepticus. Neuroscience 2010 Jun 30;168(2):443-50. Link to paper here.

17. Engel T, Murphy BM, Hatazaki S, Jimenez-Mateos EM, Concannon CG, Woods I, Prehn JH, Henshall DC. Reduced hippocampal damage and epileptic seizures after status epilepticus in mice lacking proapototic Puma. FASEB J 2010 Mar 24(3):853-61. Link to paper here.

16. Murphy BM, Engel T, Paucard A, Hatazaki S, Mouri G, Tanaka K, Tuffy LP, Jimenez-Mateos EM, Woods I, Dunleavy M, Bonner HP, Meller R, Simon RP, Strasser A, Prehn JH, Henshall DC. Contrasting patterns of Bim induction and neuroprotection in Bim-deficient mice between hippocampus and neocortex after status epilepticus. Cell Death Differ 2010 Mar 17(3):459-68. Link to paper here.

15. Avila J, Gómez de Barreda E, Engel T, Pérez M, Martín-Maestro P, Fuster-Matanzo A, Goñi-Oliver P, Lucas JJ, Hernández F. Tau kinase overexpression induces dentae gyrus degeneration. Neurodegener Dis. 2010, 7(1-3):13-5. Link to paper here.

14. Bunk EC, König H-G , Bernas T, Engel T, Henshall DC, Kirby BP and Prehn JH. BH3-only proteins BIM and PUMA in the regulation of survival and neuronal differentiation of newly generated cells in the adult mouse hippocampus. Cell Death Dis 2010; 1: e15; doi:10.1038. Link to paper here.

13. Engel T, Henshall D. Apoptosis, Bcl-2 family proteins and caspases: the ABCs of seizure-damage and epileptogenesis? Int J Physiol Pathophysiol Pharmacol 2009 Mar 1:97-115. Link to paper here.

12. Kuroki K, Virard I, Concannon CG, Engel T, Woods I, Taki W, Plesnila N, Henshall DC, Prehn JH. Effects of transient focal cerebral ischemia in mice deficient in puma. Neuroscience Letters 2009 Feb 451(3):237-40. Link to paper here.

11. Engel T, Goñi-Oliver P, Gómez-Ramos P, Moran MA, Lucas JJ, Avila J, Hernández F. Hippocampal neuronal subpopulations are differentially affected in double transgenic mice overexpressing FTDP-17 tau and GSK-3beta. Neuroscience 2008 Dec 157(4):772-80. Link to paper here.

10. Engel T, Goñi-Oliver P, Gómez de Barreda E, Lucas JJ, Hernández F, Avila J. Lithium, a potential protective drug in Alzheimer’s disease. Neurodegenerative Disease 2008, 5(3-4):247-9. Link to paper here.

9. Mouri G, Jimenez-Mateos E, Engel T, Dunleavy M, Hatazaki S, Paucard A, Matsushima S, Taki W, Henshall DC. Unilateral hippocampal CA3-predominant damage and short latency epileptogenesis after intra-amygdala microinjection of kainic acid in mice. Brain Research 2008 Jun 1213:140-51. Link to paper here.

8. Concannon CG, Ward MW, Bonner HP, Kuroki K, Tuffy LP, Bonner CT, Woods I, Engel T, Henshall DC, Prehn JH. NMDA receptor-mediated excitotoxic neuronal apoptosis in vitro and in vivo in an ER stress and PUMA independent manner. J Neurochem. 2008 May 105(3):891-903. Link to paper here.

7. Engel T, Murphy BM, Schindler CK, Henshall DC. Elevated p53 and lower MDM2 expression in hippocampus from patients with intractable temporal lobe epilepsy. Epilepsy Research 2007 Dec, 77(2-3):151-6. Link to paper here.

6. Engel T, Lucas JJ, Hernández F, Avila J. A mouse model to study tau pathology related with tau phosphorylation and assembly. Journal of Neurological Sciences 2007 Jun 257(1-2):250-4. Link to paper here.

5. Hooper C, Markevich V, Plattner F, Killick R, Schofield E, Engel T, Hernandez F, Anderton B, Rosenblum K, Bliss T, Cooke SF, Avila J, Lucas JJ, Giese KP, Stephenson J, Lovestone S. GSK-3 inhibition is integral to long-term potentiation. Eur J Neurosci. 2007 Jan5(1):81-6. Link to paper here.

4. Engel T, Goñi-Oliver P, Lucas JJ, Avila J, Hernández F. Chronic lithium administration to FTDP-17 tau and GSK-3beta overexpressing mice prevents tau hyperphosphorylation and neurofibrillary tangle formation, but pre-formed neurofibrillary tangles do not revert. Journal of Neurochemistry 2006 Dec 99(6):1445-55. Link to paper here.

3. Engel T, Hernández F, Avila J, Lucas JJ. Full reversal of Alzheimer’s disease-like phenotype in a mouse model with conditional overexpression of glycogen synthase kinase-3. J Neurosci 2006 May 26(19):5083-90. Link to paper here.

2. Engel T, Lucas JJ, Gómez-Ramos P, Moran MA, Avila J, Hernández F. Cooexpression of FTDP-17 tau and GSK-3beta in transgenic mice induce tau polymerization and neurodegeneration. Neurobiology of Aging 2006 Sep 27(9):1258-68. Link to paper here.

1. Hernández F, Engel T, Gómez-Ramos A, Pérez M, Avila J. Characterization of Alzheimer paired helical filaments by electron microscopy. Microsc Res Tech. 2005 Jul 67(3-4):121-5. Link to paper here.